The user found that Tributyrin form of Butyrate helped with their Methane + Hydrogen Sulfide SIBO/IMO. They suggest that others try it as well.
I thought to share this in case it can be useful, of course this is just my personal experience, but I have tried everything under the sun for 5 years and this helped like nothing else before. I have been struggling with Post Covid Methane + Hydrogen Sulfide SIBO/IMO for 5 years; my BM were so scarce and difficult that I felt constantly poisoned and intoxicated, with lots of neurological and allergic symptoms as a consequence. I was diagnosed with MCAS, several food intolerances, allergies, severe Histamine intolerance, had symptoms of POTS... a real mess. Nothing seemed to work, including PHGG, anti-microbials, antibiotics and probiotics (which made it way worse every single time I tried them), bitters, pro-motility supplements (ginger and artichoke) and many more... some helped a bit, but nothing resolutive. It got so bad that I was having a BM a week, with the help of osmotic laxatives or enemas; without, nothing was moving. My GI eventually prescribed Butyrate, and I tried it, but I didn't tolerate it at all; it would make me dizzy, even more bloated and made me feel sick. I tried 2 different types with the same results. Since I had tried everything else, I decided to do a last attempt and tried Butyrate in Tributyrin form: not only I tolerate it perfectly, but after a few days I started having multiple BM per day. (!) I couldn't quite believe it. It's 1 month I'm taking it every day, and I feel SO much better. And I can eat a much greater variety of foods without consequences. This is not a post to say I'm cured, I will probably have to be careful with SIBO relapses all my life, but for anyone who is thinking to try Butyrate... try ot in the Tributyrin form, be consistent, do not give up Hope. It can really change things, to a point I didn't think was possible anymore. With thoughts of strength, and much empathy, to all of you enduring this. 3.5 MONTHS LATER EDIT (March 2026): For all the people asking me if I'm still going strong, yes, I am :) I had a relapse with diarrhea, aches and mild immune symptoms two weeks ago, due to high levels of stress; what would have taken me months to heal just took me 3 days to get back in shape. Meaning, Tributyrin hasn't healed me to the point of being another person, I still have to be careful and I'm still actively working with Biome and Nervous System rebalancing, but I can absolutely confirm that the inflammation levels in my guts have decreased dramatically, and shifted that awful cascade of symptoms from "devastating and incontrollable" to "manageable with some common sense, natural supplements and quiet". I have decided to double the dosage from 500mg a day to 500mg+500mg a day with meals, in April I will do another Biome test and will check if this has made some difference. I will make sure to update this post for anybody interested.